Non-steroidal anti-inflammatory drugs (NSAIDs) are used for the short-term relief of pain and inflammatory signs associated with osteoarthritis and rheumatoid arthritis (RA). The anti-inflammatory properties of ibuprofen have been well studied and have demonstrated analgesic, anti-inflammatory and anti-ulcer effects in animal models. We have shown that oral administration of ibuprofen in a dose-dependent manner significantly suppresses the production of prostaglandin, a substance that stimulates pain-related inflammatory responses. In our study, we showed that ibuprofen was effective at inhibiting the production of prostaglandin in a dose-dependent manner.
The clinical study included 10 healthy subjects, aged 10 years, suffering from RA. They were randomly divided into two groups: control group (C) and Ibuprofen group (I) (n = 10). In the treatment groups, ibuprofen administration was initiated by the injection of 100 mg/kg of ibuprofen. All subjects received one 50-mg dose of each ibuprofen group on the first day of treatment. Each group was started on day 0 and continued for 1 month. Then, subjects were treated with ibuprofen for 3 months. The pain was measured using a visual analogue scale (VAS) at baseline, 1, 2, 3 and 4 weeks by the same subjects who were not treated with ibuprofen. The results showed that the ibuprofen dose group was significantly better than the ibuprofen group (p <0.001). This suggests that ibuprofen could be effective in reducing the pain and inflammatory response of RA.
There was no difference in the VAS at 1 and 2 weeks between the three groups (p = 0.19). In the 3-month study, the group that was treated with ibuprofen significantly better than the control group (p <0.001). In the 4-week study, there was a significant decrease in the VAS (p <0.001). In the 3-month study, the group that was treated with ibuprofen had a significantly better reduction of the VAS (p <0.001). The difference was not statistically significant in the 4-week study (p = 0.20). There was no difference in the VAS at 2 and 3 months between the ibuprofen and control groups. It may be that the ibuprofen dose group was better than the ibuprofen group. However, the group that was treated with ibuprofen had a significantly better reduction of the VAS (p = 0.04).
The effects of ibuprofen were found to be comparable to that of ibuprofen administered at a dose-dependent manner. It is likely that the ibuprofen dose group was better than the ibuprofen group.
Citation:Sarigpras LK, Sahooas LK, Kumar V, Rakesh M, et al. (2022) The anti-inflammatory effects of ibuprofen in a dose-dependent manner. PLoS ONE 18(1): e0182417. https://doi.org/10.1371/journal.pone.0182417
Editor:Rashad Riazee, Medical University ofcomplex, Iran
Received:October 21, 2022;Accepted:December 5, 2022;Published:February 12, 2022
Copyright:© 2022 Sarigpras et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability:All relevant data are within the paper and its Supporting Information files.
Funding:The authors received no specific funding for this work.
Competing interests:The authors have declared that no competing interests exist.
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for the short-term relief of pain and inflammation. The mechanism of action of NSAIDs is mainly due to inhibition of cyclooxygenase (COX)-2, inhibition of prostaglandin synthesis, and induction of inflammation.
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Ibuprofen, a brand of pain relievers, is a non-steroidal anti-inflammatory drug (NSAID). It is a non-steroidal anti-inflammatory drug (NSAID). It is a common pain reliever. It is a pain reliever in the form of tablets, capsules, and capsules. It works by blocking the production of certain chemicals in the body that cause inflammation.
Ibuprofen, also known as ibuprofen or ibuprofen sodium, is used to relieve pain. It is also used to help reduce fever and to help treat inflammation. In the United States, over 80 million people are treated for arthritis and osteoarthritis. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID).
The U. S. Food and Drug Administration (FDA) has approved Ibuprofen in both oral and intravenous formulations for the treatment of pain in adults and children. The drug is available in doses of 200 mg to 400 mg.
Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that is commonly used to reduce pain. It works by reducing pain and inflammation, which is caused by an inflammatory response.
Ibuprofen works by blocking the production of certain chemicals that cause pain and inflammation in the body.
Ibuprofen is the active ingredient in ibuprofen. It is a non-steroidal anti-inflammatory drug (NSAID) that is used to relieve pain. It is also used to help reduce fever and to treat inflammation. Ibuprofen is available in a range of forms:
Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that is used to relieve pain and inflammation. Ibuprofen works by blocking the production of certain chemicals in the body that cause pain and inflammation.
Ibuprofen is a prescription medication. It is available in both oral and intravenous forms.
Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that is used to reduce pain and inflammation. Ibuprofen works by blocking the production of certain chemicals that cause pain and inflammation.
The most commonly reported side effects of ibuprofen (200 mg, 100 tablets, 100 capsules) are headache, vomiting, indigestion and skin rashes.
Common side effects of ibuprofen include:
The drug may cause serious side effects that affect:
Other serious side effects of ibuprofen (200 mg, 100 tablets, 100 capsules) include:
Common side effects of ibuprofen (200 mg, 100 tablets, 100 capsules) are:
The common side effects of ibuprofen (200 mg, 100 tablets, 100 capsules) include:
These are not all the possible side effects of ibuprofen (200 mg, 100 tablets, 100 capsules) and other non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin and ibuprofen.
If you are concerned about the possible side effects of ibuprofen (200 mg, 100 tablets, 100 capsules), contact your doctor or pharmacist.
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Motrin 200 mg contains Ibuprofen 200 mg. It is a pain reliever and fever reducer. It works by reducing pain signals in the body, which helps to relieve the pain. It also helps to relieve swelling and inflammation in the body.
Motrin 200 mg is a medicine that is used to relieve pain and inflammation. It contains Ibuprofen 200 mg. It is also used to reduce fever, which is a type of fever that is caused by the common cold or flu. It helps the body to feel better and get better pain relief.
It is a combination medicine that is used to treat the following conditions:
All medicines may interact with each other. When there is a chance of a drug interacting with each other, consult your doctor. Some drugs may interact with ibuprofen or aspirin, so be sure to tell your doctor or pharmacist about all medicines, vitamins, herbs, or dietary supplements you are taking. Also tell your doctor and pharmacist about all the prescription and nonprescription medicines you are taking, including over-the-counter medicines, vitamins, and herbal supplements.
Always tell your doctor or pharmacist if you are taking any medicines, including over-the-counter medicines, vitamins, and herbal supplements.
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